Amorphous Drugs by Marzena Rams-Baron Renata Jachowicz Elena Boldyreva Deliang Zhou Witold Jamroz & Marian Paluch

Author:Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz & Marian Paluch
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Visualization presented in Fig. 5.2 is just a simplification of a very complex problem. For instance, the occurrence of several polymorphic forms of crystalline API may lead to the occurrence of more than one nucleation zone as indicated for indomethacin [12] or nilutamide [13]. In practice, the probability of nucleation or crystal growth at certain thermodynamic conditions depends on various factors. For clarity one can divide them as (1) thermodynamic (free energy for crystallization, configurational entropy , interfacial free energy between crystalline phase and amorphous phase), (2) kinetic and (3) intermolecular. Additionally, the influence of external conditions (such as mechanical stress , humidity, preparation method etc.) will also influence the overall crystallization behavior of amorphous API .

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